Genetic perturbations emerged as a powerful experimental approach to investigate the function of genes and other genomic elements, and to identify potential therapeutic targets for various diseases.Large amounts of genetic perturbation data have already been generated, with even larger and more diverse datasets expected to be produced in the near future. However, the lack of standardisation and accessibility of these datasets hinders their effective utilisation by the research community.The Perturbation Catalogue acts as a central hub for collecting, cleaning, curating and standardising genetic perturbation data from various sources, making it easily accessible and usable for both academic and industrial researchers. The Perturbation Catalogue provides a user-friendly interface and access to powerful tools for data exploration, visualisation and analysis. The data are harmonised and metadata annotated to ensure consistency, cross-study comparability and utility for Machine Learning (ML) applications.This webinar acts as a brief introduction to the field of genetic perturbations, the challenges associated with data accessibility and standardisation, and how the Perturbation Catalogue aims to address these issues. It also provides a hands-on demonstration of the Perturbation Catalogue web portal, showcasing its features and capabilities for data exploration and retrieval.