Recorded webinar

From variant to drug target: using the expanded Open Targets Platform to explore the genetics of target discovery

The Open Targets Platform is a comprehensive research tool that supports systematic identification and prioritisation of potential therapeutic drug targets.‌ By integrating publicly available datasets along with data generated by the Open Targets consortium, the Platform builds and scores target-disease associations.Earlier this year, the Platform was expanded through the inclusion of variant, study, and credible set information. The Platform now includes comprehensive variant annotation and the results of state-of-the-art large scale statistical analysis, including fine-mapping, colocalisation, and locus-to-gene assignment across all complex and molecular traits. Drawing from the GWAS Catalog, the eQTL Catalogue, FinnGen, the UK Biobank Pharma Proteomics Project and more, users can browse over 2.6 million credible sets to build more robust therapeutic hypotheses.This webinar will provide an introduction to the capabilities and use cases for the Open Targets Platform, and demonstrate the impact of the newly introduced data. These allow you to dig deeper into the GWAS evidence for a target-disease association, explore our analyses of GWAS and molecular QTL studies, and relevant annotation data.

Resource type: Recorded webinar

Scientific topics: Drug discovery


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