ChEMBL is a database of bioactivity for drugs and drug like compounds. This webinar provides an overview of the chemical biology resources at EMBL-EBI focusing on the ChEMBL database. In the first part, the webinar describes the structure of ChEMBL, how data is integrated and curated, and how you can access the information within ChEMBL. In the second part, some worked examples based on drug discovery scenarios have been illustrated. Each worked example will be accompanied by guidance and a demonstration showing how the ChEMBL interface can be used to extract relevant information for drug discovery initiatives.