In this webinar, we will give an overview of how single-cell and spatial genomics technologies are used to address challenges from complex tissue atlases and resolve cellular wiring diagrams of tissues in health and disease. Using multi-modal tissue atlassing from scRNA-seq, Visium and Xenium, we demonstrate the power to discover the rules of two neurological conditions. First, leveraging single-cell spatial transcriptomics of autism susceptibility genes in the developing human brain, we discovered convergence of genes in thalamic circuits. Second, we present GBM-space, a deeply profiled multi-modal map of glioblastoma tumour tissues across multiple sites, and identified novel cellular and tissue framework unifying glioblastoma tumour heterogeneity. This event is part of a broader webinar series on spatial transcriptomics. For more information about the series and its webinars, please visit the following link:  “Decoding spatial transcriptomics through sequences, pixels, and bioinformatics”.