Date: 14 November 2018

A cornerstone of modern molecular biology is the electronic transfer of annotations form a few experimentally characterised sequences to the vast number being determined from DNA modern sequencing technologies. In general, sequences that are evolutionarily related share some degree of similarity, and sequence-search algorithms use this principle to identify homologs. The requirement for a fast and sensitive sequence search method led to the development of the HMMER software and associated website housed at EMBL-EBI, which in the latest version, uses a combination of sophisticated acceleration heuristics and mathematical and computational optimisations to enable the use of profile hidden Markov models (HMMs) for sequence analysis.

In this webinar, we will cover some of the basics about the HMMER algorithm and the use of the HMMER via the website.  

Contact: Melissa Burke -

Keywords: Open Targets Platform, Cross domain (cross-domain), Chemical biology (chemical-biology), Drug discovery, Drug target identification, UniProt: The Universal Protein Resource, Proteins (proteins), UniRule, ARBA, Automated annotation, MetaboLights: Metabolomics repository and reference database, Chemical Entities of Biological Interest, ChEBI, Metabolites, Molecular building blocks of life, Human Cell Atlas Data Coordination Platform, Single-cell transcriptomics, HCA data portal, Programmatic access, API, Python, Complex Portal, macromolecular assembly, InterPro, Boolean modelling, Europe PubMed Central, Literature (literature), Open access, Protein Data Bank in Europe - Knowledge Base, 3D structure, AlphaFold Database, DeepMind, Artificial intelligence, AI, Structure prediction, cancer, Boolean, Ensembl Genomes, DNA & RNA (dna-rna), European Nucleotide Archive, Data archive, Raw sequencing data, RNAcentral, Non-coding RNA, ncRNA, GPU, Data protection, Job dispatcher, Bioimage analysis resource, Accessibility, Missense variation, Biostatistics, Rfam, non-coding RNA, Infernal software, Sequence annotation, Root microbiome, Abiotic stress, land management, Plant genotype, Plant webinar series, HPC, database development, cross-linked databases, Plant database, data infrastructure, Plant breeding, Data standards, data managemnet, data sharing, Hyb-Seq method, Flowering plants, Crop improvement, Pangenomics, Pangenomes, Virtual humans, Drug-target identification, plant-microbe interactions, Spatial transcriptomics, Plant research, Drug targets, Machine learning, Mathematical modelling, plant science, Data integration, plant-environment interaction, Phenotyping, field phenotyping, Deep phenotyping, EOSC-Life, NHGRI-EBI GWAS Catalog, clinical data, genome-wide association, Proteomics, Proteomes, Peptide search, plants, European Variation Archive, EVA, Variant clusters, Variant data annotation, Constraint-based metabolic modelling, UniProt knowledgebase, protein variant impact, disease-associated protein variants, Bioethics, FAIR principles, ELSI, cohort data, translational research, BioModels database, Mathematical modeling, Reproducibity, Systems biology models, workflows, federated analysis, polygenic risk scores, IntAct Molecular Interaction Database, PSICQUIC, IMEx, Complex portal, Agent-based modelling, Macrophages, Tumorigenesis, Ensembl, Training (Training), On-demand, teaching, introduction, Building blocks, Data analysis, COSMIC, Cancer mutation, Somatic mutation, UniFIRE, Protein annotation, ChEMBL: Bioactive data for drug discovery, Chemical compounds, drug-like molecules, Chemogenomics, Biocurator, Programming, Data management, Green Algorithms, Open data, Environmental impact, Carbon footprint, HPC workflows, Orchestrator, Gene expression (gene-expression), Chemosensitivity assay, Experimental protocols, Drug screening, MICHA, European Genome-phenome Archive, EGA, restricted access, UniProt, Introduction, UniProtKB, Proteome, Protein Data Bank in Europe, genes, Introductory, GDPR, Data security, Expression Atlas, Pfam, protein sequence search, Domain architecture, Protein taxonomy, Beginner, AI structure prediction, COVID-19, Coronavirus, COVID-19 Data Portal, Virology, Computational simulations, Signalling prior knowledge, Cancer therapy response, PRIDE: The Proteomics Identifications Database, protein structure prediction, AI system, Competency framework, Publication, Journal club, Preprints, Aggregated view, Structural similarity, PPI networks, Cell signaling, Malaria, Biological networks, Graph theory, Building biological networks, Biocuration, Information Manager, Industry, Rare-variant, Variant association, SKAT, Sensitive data, Human cohort data, FAIR, Gene Ontology, International Mouse Phenotyping Consortium Portal, Biocurators, biocuration, programming skills, training, career development, Cell-level simulations, Personalised medicine, PerMedCoE, Single cell, Phenotype, Genome-Wide Association Studies, Genome, Signaling networks, BioImage Archive, REST, Funding, UniChem: Chemical Structure Cross-referencing, Bioactivity data, Drug-like compounds, BioStudies Database, EBI Search, Finding data, World Sight Day, Eye development, Eye disease, Open software, Metadata, Web Services, Dbfetch, Database fetch, programmatic access, Open Targets, Protein structure prediction, Colab notebooks, RESTful API, RESTful Web Services, PDBe, Ligand binding sites, Protein families, Protein functional analysis, Protein sequences, Data curation, Biomolecular sequences, Reactome pathways database, ReactomeGSA, scRNA-seq, Multiomics, Cytoscape, PsyArXiv, Psychology, Bioactive data, Drug-like molecules, Biological studies, Literature, Neurodegenerative disorders, RNA families, Data sharing, Molecular visualisation, Molecular structures, Electron density maps, EBI BioSamples Database, BioSamples, Data Use Ontology, DUO, ELIXIR, Ensembl Variant Effect Predictor, Variant Effect Predictor, VEP, Variation data, Annotation, Literature search, Publications, Macromolecular complexes, UniProt Align, UniProt BLAST, Sequence analysis tools, Multiple sequence alignments, SciLite annotation, Text mining, MGnify, Microbiome, Environment, Variant data, Citations, UniProt Disease Portal, ENA Sequence Search, Pathway analysis, Single cell RNA-seq, Data visualisation, GitHub, Ensembl Rapid Release, Graph database, protein, Gene function, Mouse models, IMPC, Mammalian Phenotype Ontology, Mouse knockouts, Xenograft models, Cancer, EurOPDX, InterProScan, Enzyme Portal, Metabolism, PDBe-KB, Interpro API, Europe PMC, PubMed, Protein function, Preprints, SARS-CoV-2, Genome browser, Vertebrate genomes, Comparative genomics, Drug-like properties, eQTL Catalogue, Galaxy, Single Cell Expression Atlas, Drop-seq data, SCEA, PDX, UniParc, UniRef, Genes, GENCODE, Gene annotation, Clinical genomics, Genome3D, Genome annotations, Protein domain prediction, Functional annotation, UniFire, Gene expression, Differential expression, Gene regulation, Enzyme-related information, Alzheimer's Disease, Variant and disease, Enzyme annotation, Rhea, ENA, Open-access data archive, WormBase, Worm genomics, Parasite data, Wheat genome, Wheat genes, HMMER - protein homology search, Hidden Markov models, Sequence similarity search, Protein homology

Organizer: European Bioinformatics Institute (EBI)

Host institutions: EMBL-EBI

Capacity: 200

Event types:

  • Workshops and courses

Scientific topics: Proteins, Sequence analysis, Sequence search results

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