This Critical Guide in the Introduction to Bioinformatics series provides a brief outline of the UniProt protein sequence database, with a particular focus on the UniProt Knowledgebase – UniProtKB. The rationale for creating the resource, its contributing databases and the kinds of information...
An introduction to bioinformatics for bench biologists delivered as part of the EMBL Australia Masterclass on Protein Sequence Analysis http://oz-masterclass.wikispaces.com/ . Focuses on using UniProt to explore different reasons why information inferred by "direct assay" and "prediction" could...
Extensive teaching experience gained by conducting bioinformatics training courses in Kenya, Uganda, Mauritius (UoM), SriLanka, Sweden, Chile and Zimbabwe showed that it was difficult to successfully teach and demonstrate several bioinformatics resources, due to and often limited by slow Internet...
Jalview (www.jalview.org) is free-to-use sequence alignment and analysis visualisation software...0 upcoming events (1 past event)Jalview http://www.jalview.org/ https://tess.elixir-europe.org/content_providers/jalview Jalview (www.jalview.org) is free-to-use sequence alignment and analysis visualisation software that links genomic variants, protein alignments and 3D structure. Protein, RNA and DNA data can be directly accessed from public databases (e.g. Pfam, Rfam, PDB, UniProt and ENA etc.). Jalview has editing and annotation functionality within a fully integrated, multiple window interface. The sequence alignment programs Clustal Omega, Muscle, MAFFT, ProbCons, T-COFFEE, ClustalW, MSA Prob and GLProb can be run directly from within Jalview. Jalview integrates protein secondary structure prediction (JPred), generate trees, assesses consensus and conservation across sequence families. Journal quality figures can be generated from the results. The Jalview Desktop will run on Mac, MS Windows, Linux and any other platform that supports Java. It has been developed in Geoff Barton's group (www.compbio.dundee.ac.uk) in the School of Life Sciences (www.lifesci.dundee.ac.uk) at the University of Dundee with funding from the BBSRC and the Wellcome Trust. /system/content_providers/images/000/000/091/original/logo-boxg.png?1524735946
Protein Structure Modelling
This is the a workflow of protein modelling.
ELIXIR Structural Bioinformatics 3: Predicting the effect of mutation on protein function
This workflow builds on the previous training workflows in this series on building protein models and identifying functional domains or ligand binding sites - and introduces methods to predict how mutations can impact on protein function.
It is designed to lead you through the process of...
Homology Modelling with SWISS-MODEL
This is the workflow of homology modelling with the SWISS-MODEL expert system
SWISS-MODEL is a web-based integrated service dedicated to protein structure homology modelling. It guides the user in building protein homology models at [different levels of...
ELIXIR Structural Bioinformatics 2: Exploring protein domains and functional sites
This training workflow introduces how to search (using query protein sequences or structures) for protein domains, conservation and protein family information, surface and topological interfaces, and possible ligand binding sites.
It is designed to lead you through the process of finding...
Training course in Transcriptomics
Workflow for Transcirptomics course for CABANA learning
ELIXIR Structural Bioinformatics 1: Getting a structure for a protein of interest
This training workflow is designed to lead you through the process of finding experimentally-determined structures for a protein you are interested in - or predicting structure information if one is not available.
It will then help guide you through visualising that structure as a prerequisite...
EMBER: A practical guide to Bioinformatics
This practical introduces a range of Web-based databases and tools, allowing their relative strengths and weaknesses to be compared. The practical comprises several modules, each broken down into simple steps.