Educators:
Dr. Aleksandr Zlobin, Dr. Sophia Peter, Sevilay Gülesen, Max Beining, Julia Beliaeva, Christina Wüst, Antonio Sáenz Castillo (RBC) Dr. Marija Sorokina, Anne Schmieder

Date:
14-18 July 2025

Location:
Scads.AI, Humboldtstraße 25, 04105 Leipzig, Saxony, Germany

Contents:
Theoretical introduction into modern approaches of computational protein and drug design, followed by practical hands-on sessions. Technologies covered include

Rosetta and pyRosetta
AlphaFold
ProteinMPNN
RFdiffusion
BindCraft
We will discuss their value in designing

Therapeutic peptides
Vaccines
Enzymes
And other therapeutic modalities
The workshop is open for students and researchers at any career level and is free of charge. The working language of the event is English.

Learning goals:
Understand the space of available protein and drug design technologies, their application scenarios, requirements and limitations. Get experience in applying these tools to model problems. Understand practical considerations of designing proteins and drugs with particular function and therapeutic modality. Learn how to apply computational design tools in your own project.

Prerequisites:
Google account, basic knowledge of Python. Being able to bring your own laptop is appreciated, but not necessary.

Keywords:
Protein design, enzyme design, drug discovery, structure prediction, AlphaFold, ProteinMPNN, Rfdiffusion, Rosetta

Tools:
Google Colab, ColabFold, AlphaFold, PyMol, ChimeraX, Rosetta, pyRosetta, ProteinMPNN, Rfdiffusion, BindCraft