Epigenetics - DNA Methylation data analysis

DNA methylation is an epigenetic mechanism used by higher eukaryotes and involved in e.g. gene expression, X-Chromosome inactivating, imprinting, and gene silencing of germline specific gene and repetitive elements.

Questions of the tutorial:

  • What is methylation and why it cannot be recognised by a normal NGS procedure?
  • Can a different methylation influence the expression of a gene? How?
  • Which tools you can use to analyse methylation data?

Objectives of the tutorial:

  • Learn how to analyse methylation data
  • Get a first intuition what are common pitfalls.

Resource type: Tutorial

Authors: joachimwolff, dpryan79

External resources:
Epigenetics - DNA Methylation data analysis https://tess.elixir-europe.org/materials/epigenetics-dna-methylation-data-analysis DNA methylation is an epigenetic mechanism used by higher eukaryotes and involved in e.g. gene expression, X-Chromosome inactivating, imprinting, and gene silencing of germline specific gene and repetitive elements. Questions of the tutorial: - What is methylation and why it cannot be recognised by a normal NGS procedure? - Can a different methylation influence the expression of a gene? How? - Which tools you can use to analyse methylation data? Objectives of the tutorial: - Learn how to analyse methylation data - Get a first intuition what are common pitfalls.