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Scientific topics: Protein disordered structure 

  • Disorder in Disorders: Pathogenic mechanisms of Intrinsically Disordered Proteins

    27 - 31 January 2020

    Disorder in Disorders: Pathogenic mechanisms of Intrinsically Disordered Proteins https://tess.elixir-europe.org/events/disorder-in-disorders-pathogenic-mechanisms-of-intrinsically-disordered-proteins Intrinsically Disordered Proteins (IDPs) are a highly abundant class of proteins that lack stable tertiary and/or secondary structures under physiological conditions. Numerous IDPs are associated with human diseases, including cancer, cardiovascular disease, amyloidoses, neurodegenerative diseases, and diabetes. Overall, intriguing interconnections among intrinsic disorder, cell signaling, and human diseases suggest that protein conformational diseases may result not only from protein misfolding, but also from misidentification, missignaling, and unnatural or nonnative folding. The winter school will alternate lectures to practicals. During lectures, experts of the field will provide students an overview of IDP biological mechanisms that develop pathogenic phenotypes. They will explore the concepts of folding, unfolding and misfolding, highlighting their differences and similarities. Practical exercises aim at transferring to students basic skills for the study of IDPs and will revolve around the use of bioinformatic tools to solve complex problems. The school includes a half-day workshop on ELIXIR interoperability services and support for the IDP Community. 2020-01-27 09:00:00 UTC 2020-01-31 17:00:00 UTC Università degli Studi di Padova - Casa della Gioventù, Via Rio Bianco,12 Università degli Studi di Padova - Casa della Gioventù, Via Rio Bianco,12 Protein properties Protein disordered structure Bioinformatics University of Padova, Italy idpfun@ngp-net.bio.unipd.it [] PhD studentspostdoctoral researchersLife Science Researchers workshops_and_courses first_come_first_servedregistration_of_interest intrinsically disordered proteinsprotein foldingbioinformatics
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