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4 events found

Keywords: Open Targets  or Genome Mapping  or Immunity  or Diseases 

  • Open Targets Genetics at ESHG

    15 June 2019

    Sweden

    Open Targets Genetics at ESHG https://tess.elixir-europe.org/events/workshop-at-eshg In this workshop, we will introduce Open Targets Genetics Portal as part of the Open Targets ecosystem, highlighting variant-centric statistical evidence for prioritizing candidate causal variants at trait-associated loci, and identifying potential drug targets. We will present POSTGAP, a pipeline which merges genetic associations curated from literature with functional genomics, epigenetic and expression data (e.g., eQTL, promoter capture Hi-C, DNase hypersensitivity sites, regulatory elements) to resolve association signals at a locus and link each variant to its target gene(s) using a single evidence score. The portal also incorporates pre-computed fine-mapping at trait-associated loci across hundreds of UK Biobank phenotypes as well as cross-trait colocalization, furthering drug repurposing opportunities. This workshop will enable you to effectively use Open Targets Genetics to gain biological insight, prioritize genes, and inform target decision-making. Intended Audience: Attendees interested in the translational application of genetics and genomics with an emphasis on the identification of target genes of trait-associated loci, drug target identification, prioritisation and repurposing. Participants should bring their laptops for exploration of the Open Targets Genetics Portal in situ. 2019-06-15 09:00:00 UTC 2019-06-15 00:00:00 UTC Gothenburg, Sweden Gothenburg Sweden [] [] [] workshops_and_courses [] Open Targets
  • Open Targets Genetics at ESHG

    15 June 2019

    Sweden

    Open Targets Genetics at ESHG https://tess.elixir-europe.org/events/open-targets-genetics-at-eshg In this workshop, we will introduce Open Targets Genetics Portal as part of the Open Targets ecosystem, highlighting variant-centric statistical evidence for prioritizing candidate causal variants at trait-associated loci, and identifying potential drug targets. We will present POSTGAP, a pipeline which merges genetic associations curated from literature with functional genomics, epigenetic and expression data (e.g., eQTL, promoter capture Hi-C, DNase hypersensitivity sites, regulatory elements) to resolve association signals at a locus and link each variant to its target gene(s) using a single evidence score. The portal also incorporates pre-computed fine-mapping at trait-associated loci across hundreds of UK Biobank phenotypes as well as cross-trait colocalization, furthering drug repurposing opportunities. This workshop will enable you to effectively use Open Targets Genetics to gain biological insight, prioritize genes, and inform target decision-making. Intended Audience: Attendees interested in the translational application of genetics and genomics with an emphasis on the identification of target genes of trait-associated loci, drug target identification, prioritisation and repurposing. Participants should bring their laptops for exploration of the Open Targets Genetics Portal in situ. 2019-06-15 09:00:00 UTC 2019-06-15 00:00:00 UTC Gothenburg, Sweden Gothenburg Sweden [] [] [] workshops_and_courses [] Open Targets
  • Open Targets workshop - University of Oxford

    4 July 2019

    United Kingdom

    Open Targets workshop - University of Oxford https://tess.elixir-europe.org/events/open-targets-webinar-c-comend-training-in-translational-research In this workshop, we introduce Open Targets and its bioinformatics tools, namely Open Targets Platform and Open Targets Genetics, comprehensive and robust data integration resources for systematic target identification and prioritisation in drug discovery. 2019-07-04 09:00:00 UTC 2019-07-04 00:00:00 UTC Oxford, United Kingdom Oxford United Kingdom [] [] [] workshops_and_courses [] Open Targets
  • 4th Disease Maps Community Meeting - DMCM2019

    2 - 4 October 2019

    Sevilla, Spain

    Elixir node event
    4th Disease Maps Community Meeting - DMCM2019 https://tess.elixir-europe.org/events/4th-disease-maps-community-meeting-dmcm2019 The [4th Disease Maps Community Meeting] (http://disease-maps.org/DMCM2019) is hosted by the [Clinical Bioinformatics Area] (http://www.clinbioinfosspa.es/), FPS, Hospital Virgen del Rocio. **Invited Talks** * _Schizophrenia Map: Data to knowledge to data_ **Jessica Dale Tenenbaum**, Duke University at Durham, North Carolina, USA * _Logic modeling to integrate disease maps and various omics data_ **Julio Saez-Rodriguez**, RWTH-Aachen University Hospital, Aachen, Germany * _Toward whole-cell computational models for precision medicine_ **Jonathan Karr**, Icahn School of Medicine at Mount Sinai, New York, USA * _Computational approaches to tackle chemoresistance in high-grade serous ovarian cancer_ **Sampsa Hautaniemi**, Faculty of Medicine, University of Helsinki, Finland **Afternoon discussion sessions** Afternoon breakout discussion sessions are planned following the example of the 2nd Disease Maps Community Meeting in Luxembourg. We invite proposals: a title and a brief description of the topic (1 page maximum). 4-6 topics will be selected, introduced 2nd October and discussed 3rd and 4th October with summaries presented at the end to all the participants. **Abstract subimission and registration** http://disease-maps.org/DMCM2019 2019-10-02 09:30:00 UTC 2019-10-04 13:30:00 UTC Disease Maps Project Centro de Documentación Clínica Avanzada, s/n, Avda de Manuel Siurot, Sevilla, Spain Centro de Documentación Clínica Avanzada, s/n, Avda de Manuel Siurot Sevilla Spain 41013 Systems medicine Translational medicine Bioinformatics Fundación Progreso y Salud (FPS)Hospital Virgen del Rocio disease-maps-coord@googlegroups.com [] [] meetings_and_conferences [] BioinformaticsClinical BioinformaticsDiseasesDisease mapsTranslational Bioinformaticssystems medicine
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