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  • RSS Nigeria Local Group: A career in statistics and its use in science and national development

    No date given

    London, United Kingdom

    RSS Nigeria Local Group: A career in statistics and its use in science and national development https://tess.elixir-europe.org/events/rss-nigeria-local-group-a-career-in-statistics-and-its-use-in-science-and-national-development About the event: The RSS Nigeria Local Group is hosting a career talk for secondary school students. Confirmed speakers for this event include Professor O. I. Shittu (Department of Statistics, University of Ibadan) and Professor Kayode Ayinde (Department of Statistics, Federal University of Technology). The career talk will include discussions by Professor Kayode Ayinde on the discipline called statistics and its relationship with mathematics, social science, medicine, law, agriculture etc.   Professor Shittu will talk about the uses of statistics by individuals, businesses, researchers, government and the international community. Statisticians are one of the highest paid people in the world today and we will share the career prospects and opportunities for qualified statisticians.  This event is organised in collaboration with the Professional Statisticians Society of Nigeria.  For more information about Nigeria local group visit  www.rss.org.uk/nigeria Royal Statistical Society The Royal Statistical Society, London, United Kingdom The Royal Statistical Society London United Kingdom EC1Y 8LX [] [] [] workshops_and_courses [] HDRUK
  • Industrial Strength Data Science presents: "a hell of a lot of skills"

    No date given

    London, United Kingdom

    Industrial Strength Data Science presents: "a hell of a lot of skills" https://tess.elixir-europe.org/events/industrial-strength-data-science-presents-a-hell-of-a-lot-of-skills A panel discussion and networking event for those interested in the long term success of data science as a profession.   About this Event Being a data scientist involves a wide range of diverse skills, such as mathematics, statistics, programming, technical communication, problem-solving, business knowledge, machine learning, and on and on. And there are a number of routes into the discipline, from university courses, on-the-job training, self-taught & online courses, and data-intense PhDs. This jumble of skills and routes means no two data scientists look the same. Combined with the variety of domains that data scientists work in, and the innovative nature of the role, it is hard to definitively list the required skills of a data scientist. Is this ambiguity a problem? Has the time come for a professional data science body to create an accreditation system? What would be the benefits, and how could it practically operate? Wouldn't it create an elitist program, and stifle innovation? And who could possibly be the gatekeeper? What do you think? *This event will be followed by a drinks reception. We will explore these questions and more at our next "Industrial Strength Data Science" event on the evening of Thursday 25th July 2019, with a fantastic panel of speakers and contributors. Registration alongside refreshments will be open from 6.30 pm See you there!   Royal Statistical Society The Royal Statistical Society, London, United Kingdom The Royal Statistical Society London United Kingdom EC1Y 8LX [] [] [] workshops_and_courses [] HDRUK
  • Significance Magazine Drinks Reception at JSM 2019

    No date given

    London, United Kingdom

    Significance Magazine Drinks Reception at JSM 2019 https://tess.elixir-europe.org/events/significance-magazine-drinks-reception-at-jsm-2019 About the event: Significance editor Brian Tarran will host a reception at the 2019 Joint Statistical Meetings. Magazine readers and contributors, including RSS Fellows, are invited to attend. Spaces are limited, so to reserve a place at this reception please, email significance@rss.org.uk Royal Statistical Society The Royal Statistical Society, London, United Kingdom The Royal Statistical Society London United Kingdom EC1Y 8LX [] [] [] workshops_and_courses [] HDRUK
  • ICSTA'19 - The International Conference of Statistics: Theory and Applications

    No date given

    London, United Kingdom

    ICSTA'19 - The International Conference of Statistics: Theory and Applications https://tess.elixir-europe.org/events/icsta-19-the-international-conference-of-statistics-theory-and-applications The goal of ICSTA'19 is to gather scholars from all over the world to present advances in each of the specialized fields and to foster an environment conducive to exchanging ideas and information.  This conference will also provide an ideal environment to develop new collaborations and meet experts on the fundamentals, applications, and products of the mentioned fields.  Interested authors, researchers, and industrial experts are invited to register for the conference that best resonates with their technical background.  Royal Statistical Society The Royal Statistical Society, London, United Kingdom The Royal Statistical Society London United Kingdom EC1Y 8LX [] [] [] workshops_and_courses [] HDRUK
  • RSS Highland Local Group: Can simple tests based on randomisation be used in assessment of research misconduct?

    No date given

    London, United Kingdom

    RSS Highland Local Group: Can simple tests based on randomisation be used in assessment of research misconduct? https://tess.elixir-europe.org/events/rss-highland-local-group-can-simple-tests-based-on-randomisation-be-used-in-assessment-of-research-misconduct Speaker: Dr Mark Bolland, Associate Professor, Dept of Medicine, University of Auckland About the event: A number of high profile cases of research misconduct have occurred where individuals have published numerous clinical trials with fabricated data over many years. Systematic reviewers sometimes identify outlying trials with concerning issues or where the data seem too good to be true. Several cases of research misconduct have now been identified by using simple tests to try and identify whether the trial results are similar to what would be expected if randomisation took place. In this talk, I will present the results of simple techniques we have used in large cases of research fraud, and discuss how they can be used and their problems. The techniques might be useful for people undertaking systematic reviews (e.g. clinical trialists when developing a trial protocol) who come upon outlying trial results or trials that raise concern about research integrity.     Refreshments from 3.30pm with talk starting at 4pm   Royal Statistical Society The Royal Statistical Society, London, United Kingdom The Royal Statistical Society London United Kingdom EC1Y 8LX [] [] [] workshops_and_courses [] HDRUK
  • RSS 2019 Annual General Meeting

    No date given

    London, United Kingdom

    RSS 2019 Annual General Meeting https://tess.elixir-europe.org/events/rss-2019-annual-general-meeting The one hundred and eighty-fifth annual general meeting of the Society shall take place on: Tuesday 3 September 2019 at 12.50pm in ICC Belfast at the RSS 2019 Annual Conference. It is free to attend. Read the minutes for the 2018 AGM (PDF). Read the agenda for the 2019 meeting (PDF). Download our 2018 annual report and accounts (PDF). If you are attending the RSS Conference, there is no need to RSVP for the AGM. However, if you are not attending the RSS Conference, please email the RSS in advance to let us know that you will be attending. Agenda and further details TBA. Royal Statistical Society The Royal Statistical Society, London, United Kingdom The Royal Statistical Society London United Kingdom EC1Y 8LX [] [] [] workshops_and_courses [] HDRUK
  • Extended Discussion Meeting: Signs and sizes: understanding and replicating statistical findings

    No date given

    London, United Kingdom

    Extended Discussion Meeting: Signs and sizes: understanding and replicating statistical findings https://tess.elixir-europe.org/events/extended-discussion-meeting-signs-and-sizes-understanding-and-replicating-statistical-findings L. Held (University of Zurich) ‘A new standard for the analysis and design of replication studies’ A new standard is proposed for the evidential assessment of replication studies. The approach combines a specific reverse Bayes technique with prior-predictive tail probabilities to define replication success. The method gives rise to a quantitative measure for replication success, called the sceptical p-value. The sceptical p-value integrates traditional significance of both the original and the replication study with a comparison of the respective effect sizes. It incorporates the uncertainty of both the original and the replication effect estimates and reduces to the ordinary p-value of the replication study if the uncertainty of the original effect estimate is ignored. The framework proposed can also be used to determine the power or the required replication sample size to achieve replication success. Numerical calculations highlight the difficulty of achieving replication success if the evidence from the original study is only suggestive. An application to data from the Open Science Collaboration project on the replicability of psychological science illustrates the methodology proposed. To be published in Series A; for more information go to the Wiley Online Library. K. Rice (University of Washington, Seattle), T. Bonnett (National Laboratory for Cancer Research, Frederick) and C. Krakauer (University of Washington, Seattle) ‘Knowing the signs: a direct and generalizable motivation of two-sided tests’ Many well-known problems with two-sided p-values are due to their use in hypothesis tests, with ‘reject–accept’ conclusions about point null hypotheses. We present an alternative motivation for p-value-based tests, viewing them as assessments of only the sign of an underlying parameter, where we can conclude that the parameter is positive, negative or simply say nothing either way. Our approach is decision theoretic, but—unusually—we consider the whole set of possible utility functions available. Doing this we show how, in a specific sense, close analogues of familiar one- and two-sided tests are always the optimal decision. We argue that this simplicity could aid non-experts’ understanding and use of tests—and help them to think critically about whether or not tests are appropriate tools for answering their questions of interest. Several extensions are also considered, showing that the simple idea of determining the signs of parameters yields a rich framework for inference. To be published in Series A; for more information go to the Wiley Online Library Royal Statistical Society The Royal Statistical Society, London, United Kingdom The Royal Statistical Society London United Kingdom EC1Y 8LX [] [] [] workshops_and_courses [] HDRUK
  • RSS 2019 International Conference

    No date given

    London, United Kingdom

    RSS 2019 International Conference https://tess.elixir-europe.org/events/rss-2019-international-conference The RSS International Conference has established itself as the only conference in the UK for anyone interested in statistics and data science. Every year, over 600 statisticians and data scientists gather from all sectors and from over 30 countries to share information and network, attracted by a varied programme of talks and workshops. The 2019 conference will, once again, be organised by ‘streams’ allowing in-depth focus on specialised topics as well as broader presentations on new developments and thinking in statistics. Registration is now open   Important dates Submission Deadline for Contributed Talk Abstracts           17 April 2019 Submission Deadline for Rapid-fire talks                              7 May 2019 Early Registration Deadline                                                  5 June 2019 Submission Deadline for Contributed Poster Abstracts        1 July 2019 Second Registration Deadline                                               31 July 2019  Royal Statistical Society The Royal Statistical Society, London, United Kingdom The Royal Statistical Society London United Kingdom EC1Y 8LX [] [] [] workshops_and_courses [] HDRUK
  • Basic Statistics: Understanding & Analysing Data

    No date given

    London, United Kingdom

    Basic Statistics: Understanding & Analysing Data https://tess.elixir-europe.org/events/basic-statistics-understanding-analysing-data-ee873b88-cc8f-4adc-b507-d8d4e0101280 Tutor - Jenny Freeman Level - Foundation CPD 12 Hours This two day course will help you to understand some basic statistical concepts and develop a strategy for approaching a simple data analysis. Royal Statistical Society The Royal Statistical Society, London, United Kingdom The Royal Statistical Society London United Kingdom EC1Y 8LX [] [] [] workshops_and_courses [] HDRUK
  • Growth-fragmentation phenomena

    No date given

    London, United Kingdom

    Growth-fragmentation phenomena https://tess.elixir-europe.org/events/growth-fragmentation-phenomena About the Event Many natural and social phenomena exhibit behaviour of growth and division, or fragmentation, from social groupings to cell division and protein polymerisation. Mathematically, the topic ties together problems in spectral theory and the probability and statistics of trees. This workshop presents perspectives on growth-fragmentation phenomena from probability, statistics and differential equations. Marie Doumic - Estimating the division rate and kernel in fragmentation equations Jere Koskela - Statistical inference under latent trees  Robin Stephenson - Multi-type fragmentation trees as scaling limits of Markov branching trees Registration is required. Please register here.   Royal Statistical Society The Royal Statistical Society, London, United Kingdom The Royal Statistical Society London United Kingdom EC1Y 8LX [] [] [] workshops_and_courses [] HDRUK
  • FEBS: In Silico Systems Biology: Network Reconstruction, Analysis and Network-based Modelling

    No date given

    Elixir node event
    FEBS: In Silico Systems Biology: Network Reconstruction, Analysis and Network-based Modelling https://tess.elixir-europe.org/events/febs-in-silico-systems-biology-network-reconstruction-analysis-and-network-based-modelling Alison Barker Alison Barker [] Alison Barker [] [] [] [] HDRUK
  • EBI - Joint EBI-Wellcome Trust Proteomics Bioinformatics workshop

    No date given

    Elixir node event
    EBI - Joint EBI-Wellcome Trust Proteomics Bioinformatics workshop https://tess.elixir-europe.org/events/ebi-joint-ebi-wellcome-trust-proteomics-bioinformatics-workshop Yvonne Hitching Yvonne Hitching [] Yvonne Hitching [] [] [] [] HDRUK
  • Using the Ensembl Genome Browser

    No date given

    Elixir node event
    Using the Ensembl Genome Browser https://tess.elixir-europe.org/events/using-the-ensembl-genome-browser-76bbe497-3738-4bde-b9cc-0e70d85e67eb Using the Ensembl Genome Browser Using the Ensembl Genome Browser [] [] [] [] [] HDRUK
  • Induction Course for New Lecturers in the Mathematical Sciences 2019

    No date given

    London, United Kingdom

    Induction Course for New Lecturers in the Mathematical Sciences 2019 https://tess.elixir-europe.org/events/induction-course-for-new-lecturers-in-the-mathematical-sciences-2019 About the Course: Through a community initiative supported by the Institute of Mathematics and its Applications, the Isaac Newton Institute for Mathematical Sciences and the Heads of Departments of Mathematics Sciences (HoDoMS) and endorsed by the Royal Statistical Society, the Operational Research Society and the London Mathematical Society, we are delighted to announce that in September 2019 the two-day Induction Course for lecturers new to teaching mathematics and statistics within Higher Education will once again take place. The Induction Course for New Lecturers in the Mathematical Sciences has been designed by the mathematics community so that it is ideally suited for anyone who is new to or has limited experience teaching mathematics or statistics within UK higher education. It will be delivered by individuals with significant experience of teaching in the mathematical sciences and will focus upon the specific details and issues that arise in mathematics and statistics teaching and learning within higher education including topics such as: Registration: Registration is open via https://my.ima.org.uk/ Further information available: https://ima.org.uk/11361/induction-course-for-new-lecturers-in-the-mathematical-sciences-2019/ Conference arranged with support by:   Royal Statistical Society The Royal Statistical Society, London, United Kingdom The Royal Statistical Society London United Kingdom EC1Y 8LX [] [] [] workshops_and_courses [] HDRUK
  • The Essentials of Survey Research Design

    No date given

    London, United Kingdom

    The Essentials of Survey Research Design https://tess.elixir-europe.org/events/the-essentials-of-survey-research-design-b6b86933-b413-4e2f-87de-a3e19eabb789 Dr Pamella Campanelli Level - Foundation CPD 12 hours This course looks at each of the quality areas for producing a successful and efficient quantitative survey. It covers all the major methods of data collection (quantitative interviewing, web and paper self-completion) as well as all the key aspects of the survey process from initial design through implementation through post-field processing.   Royal Statistical Society The Royal Statistical Society, London, United Kingdom The Royal Statistical Society London United Kingdom EC1Y 8LX [] [] [] workshops_and_courses [] HDRUK
  • Survival Analysis

    No date given

    London, United Kingdom

    Survival Analysis https://tess.elixir-europe.org/events/survival-analysis-53885de6-8237-43df-8aed-cb28c89e655d Presented by D Collett Level - Professional CPD 12 hours This two day course describes some of the more advanced methods of survival analysis and illustrates their practical application using SAS and R.   Royal Statistical Society The Royal Statistical Society, London, United Kingdom The Royal Statistical Society London United Kingdom EC1Y 8LX [] [] [] workshops_and_courses [] HDRUK
  • Learning more from the practice of educational trials - some methodological developments

    No date given

    London, United Kingdom

    Learning more from the practice of educational trials - some methodological developments https://tess.elixir-europe.org/events/learning-more-from-the-practice-of-educational-trials-some-methodological-developments About the event: The meeting follows up the Social Statistics Section meeting in 2015 which identified the need to power trials to understand their impact on disadvantaged groups. It is also linked to the afternoon meeting reviewing the experience of 100 years of trials in education (separate registration required). This event will be of a more technical nature, aimed at researchers interested in education trial development, and in understanding social inequalities in policy experiments.   Speakers Chair: Harvey Goldstein (University of Bristol) Zhi Min Xiao (University of Exeter) -  "The case against Perfection in the Mean: Pupil Advantage Index as a step towards Personalised Intervention" Ben Weidmann (Harvard University & Education Endowment Foundation) - "Lurking inferential monsters? Quantifying selection bias in non-experimental evaluations of school programs"   Event Fees: Concessionary Fellow:£15 CStat/GradStat: £18 Fellows: 20 None of the above: £30 The registration fee includes lunch and refreshments throughout the morning. Registration with payment is required. Please register here.   Royal Statistical Society The Royal Statistical Society, London, United Kingdom The Royal Statistical Society London United Kingdom EC1Y 8LX [] [] [] workshops_and_courses [] HDRUK
  • 100 years of education trials: no significant difference?

    No date given

    London, United Kingdom

    100 years of education trials: no significant difference? https://tess.elixir-europe.org/events/100-years-of-education-trials-no-significant-difference About the event: To mark the centenary of the first recorded randomised controlled trial (RCT) in education, the Royal Statistical Society and NFER are bringing together leading figures in the field of education research to address the key challenges faced by education trials today. This forum invites you to celebrate the contribution trials have made to understand what works in education, and to consider how they can have more impact in advancing practice and improving outcomes for learners.   Programme: Welcome address Carole Willis, Chief Executive at NFER   The history and future of randomised controlled trials in education Professor Carole Torgerson FAcSS, Professor of Education at Durham University   TBC – A recent systematic review of education RCTs Professor Paul Connolly, Queen’s University Belfast   Are rigorous educational trials producing useful evidence? Dr Hugues Lortie-Forgues, Lecturer at University of York   Reflections on 8 years of commissioning education trials: What could we do different? Camilla Nevill, Head of Evaluation at EEF   English Education RCTs in 2019 – how far have we come? Dr Ben Styles, Head of Trials Unit at NFER   ‘Unzipping’ the EEF toolkit: RCTs and the role of meta-analysis Professor Steve Higgins, Professor of Education at Durham University   RCTs: what do they mean for teachers and school leaders? Alex Quigley, National Content Manager at EEF and former teacher   Panel: Improving the quality of education RCTs Professor Sheila Bird OBE (MRC Biostatistics Unit), Josh Hillman (Nuffield Foundation), Professor Jeremy Hodgen (UCL Institute of Education), and Dr Riikka Hofmann (University of Cambridge) Registration alongside tea and coffee available from 1.30 pm   This event will be followed by a drinks reception from 6.30pm - 7.30pm   UNFORTUNATELY, THIS EVENT IS SOLD OUT - to be included in the waiting list, please, email l.martinez@rss.org.uk   The event will be recorded and will be preceded by a methodology workshop in the morning (click here) Royal Statistical Society The Royal Statistical Society, London, United Kingdom The Royal Statistical Society London United Kingdom EC1Y 8LX [] [] [] workshops_and_courses [] HDRUK
  • Applied Statistics 2019

    No date given

    London, United Kingdom

    Applied Statistics 2019 https://tess.elixir-europe.org/events/applied-statistics-2019 Applied Statistics 2019 will be held in Ribno (Bled), Slovenia, 22-25 September 2019. This year three distinguished speakers will give plenary talks:   Mitchell H. Gail, USA   Ruth Pfeiffer, USA   Christoph Stadtfeld, Switzerland Please visit conferences.nib.si/AS2019/ for further details. Royal Statistical Society The Royal Statistical Society, London, United Kingdom The Royal Statistical Society London United Kingdom EC1Y 8LX [] [] [] workshops_and_courses [] HDRUK
  • RSS South Wales: Open Data – The promised data revolution?

    No date given

    London, United Kingdom

    RSS South Wales: Open Data – The promised data revolution? https://tess.elixir-europe.org/events/rss-south-wales-open-data-the-promised-data-revolution About the event: "The benefits of Open Data are diverse and range from improved efficiency of public administrations, economic growth in the private sector to wider social welfare." - European Data Portal Recent years have seen an increased focus on Open Data. This has raised the expectations placed on producers of statistics and offered new opportunities for those who consume data. So, how far have we progressed and what has been the impact on producers and consumers of data? This event, hosted by the RSS South Wales Local Group, will consist of four short presentations followed by a panel led discussion. There will be an opportunity for networking following the talks, and light refreshments will be provided. Speakers:  Professor Tom Crick, Swansea University, School of Education Dr Scott Orford, Cardiff University, School of Geography and Planning Rob Grant and Darren Barnes, Office for National Statistics TBC, Office of the Chief Digital Officer, Welsh Government Full Abstracts available here  Attendance is free and open to all, whether fellows of the RSS or not, but pre-registration is required.   Royal Statistical Society The Royal Statistical Society, London, United Kingdom The Royal Statistical Society London United Kingdom EC1Y 8LX [] [] [] workshops_and_courses [] HDRUK
  • Introduction to R & Statistical Modelling in R

    No date given

    London, United Kingdom

    Introduction to R & Statistical Modelling in R https://tess.elixir-europe.org/events/introduction-to-r-statistical-modelling-in-r-13ee79fb-c544-4597-a983-c32c1535ad4a Tutor - Colin Gillespie / Jamie Owen Level - Foundation CPD 12 Hours This two day course will introduce you to the R environment for statistical computing. Day 1 focuses on entering, working with and visualising data in R. Day 2 focuses on regression modelling in R, including linear, general linear, logistic and survival models.   Royal Statistical Society The Royal Statistical Society, London, United Kingdom The Royal Statistical Society London United Kingdom EC1Y 8LX [] [] [] workshops_and_courses [] HDRUK
  • Statistics in Well-Being

    No date given

    London, United Kingdom

    Statistics in Well-Being https://tess.elixir-europe.org/events/statistics-in-well-being Speaker: Lauren Stockley (University of Plymouth) Abstract: The Office for National Statistics use four subjective measures to understand well-being in the UK. The aim of the project was to gain a further understanding as to whether other, objective, factors influence a person's well-being and if so, which of these are the most important. Principal Components Analysis was used to combine the four well-being variables for subsequent analysis. A variety of different regression techniques for modelling the data were then considered, namely classical linear regression, quantile regression and Poisson regression. The combined well-being variable was used as the response variable and the remaining variables in the dataset were used to explain it. Various techniques were considered in the linear regression analysis to select the best subset of predictors to explain a person’s well-being. The chosen model was then interpreted to determine how each variable affects well-being using the three different regression models. All models considered found very similar results when comparing how each variable explains well-being. Cross-validation was used to measure the performance of the linear and Poisson models through prediction. The linear model was found to produce well-being predictions closer to the true values than the Poisson model when evaluating the models using mean squared error. A non-parametric model, random forest regression was fit to the data and used as a way of testing the importance of predictors in the model. This analysis showed that the most important variables for explaining well-being are disability, marital status and age of respondent. Royal Statistical Society The Royal Statistical Society, London, United Kingdom The Royal Statistical Society London United Kingdom EC1Y 8LX [] [] [] workshops_and_courses [] HDRUK
  • The purpose of statistics is insight not numbers

    No date given

    London, United Kingdom

    The purpose of statistics is insight not numbers https://tess.elixir-europe.org/events/the-purpose-of-statistics-is-insight-not-numbers Speaker: Neil Sheldon Abstract: In recent years, statistics teaching has seen a welcome move away from formulae and calculation. Especially with the rise of ‘big data’, numerical processing is increasingly being done with software, and it is becoming much more important for students to learn the art and science of interpretation. This development requires teachers to change focus too, shifting their emphasis from numbers to language. As with many academic disciplines, statistics overlays everyday language with specialist meaning: one familiar example is the word ‘significant’ which means very different things in everyday use and in statistics. Research shows that parallel meanings such as this make it harder for students to understand technical concepts. Research also shows that teaching with a richer vocabulary can help to overcome this problem of understanding. But statistics is more than just an academic discipline, it is a vital element of citizenship: we all need statistical understanding to make sense of the world around us. Yet statistical data are routinely misunderstood and misinterpreted in the media. In most cases the errors arise, not from the numbers themselves, but from the confused and inaccurate language used to comment on them. Clear language is essential to clear thought. This lecture, drawing on numerous practical examples, will explore the ways in which careful use of language can help everyone – teachers, students and citizens – to understand statistics better, whether in formulating enquiries, interpreting data, or reaching trustworthy conclusions and communicating them effectively. More information: Neil Sheldon (neilsheldon.net) was a teacher for more than 40 years. He is a Chartered Statistician and a former Vice-President of the Royal Statistical Society. He was the RSS Guy Lecturer in 2007-8 and he is currently Chair of the Teaching Statistics Trust. Neil’s other academic interests include philosophy and linguistics. The Teaching Statistics Trust Lecture, (teachingstatisticstrust.org.uk), is given annually at multiple locations. It is aimed at teachers of statistics, whether specialist or non-specialist, in secondary schools, colleges and early years of university. Royal Statistical Society The Royal Statistical Society, London, United Kingdom The Royal Statistical Society London United Kingdom EC1Y 8LX [] [] [] workshops_and_courses [] HDRUK
  • Mendelian randomisation

    No date given

    London, United Kingdom

    Mendelian randomisation https://tess.elixir-europe.org/events/mendelian-randomisation Speaker: Derrick Bennett, CTSU, Nuffield Department of Population Health, University of Oxford, Big Data Institute Understanding the causal role of biomarkers in cardiovascular and other diseases is crucial in order to find effective approaches (including pharmacological therapies) for disease treatment and prevention. Classical observational studies provide naïve estimates of the likely role of biomarkers in disease development; however, such studies are prone to bias. This has direct relevance for drug development as if drug targets track to non-causal biomarkers, this can lead to expensive failure of these drugs in phase III randomised controlled trials. In an effort to provide a more reliable indication of the likely causal role of a biomarker in the development of disease, Mendelian randomisation studies are increasingly used, and this is facilitated by the availability of large-scale genetic data. This talk will give an overview of the rationale and provide a non-technical description of the methods and potential limitations of Mendelian randomisation. Examples will be given where Mendelian randomisation has provided pivotal information for drug discovery including predicting efficacy, informing on target-mediated adverse effects and providing potential new evidence for drug repurposing. Royal Statistical Society The Royal Statistical Society, London, United Kingdom The Royal Statistical Society London United Kingdom EC1Y 8LX [] [] [] workshops_and_courses [] HDRUK
  • A two-day dip into the EBI’s data resources: Understanding your data

    10 September 2007

    Elixir node event
    A two-day dip into the EBI’s data resources: Understanding your data https://tess.elixir-europe.org/events/a-two-day-dip-into-the-ebi-s-data-resources-understanding-your-data-0ad30c36-250a-4d5a-bb8d-0adcb1de5502 2007-09-10 09:00:00 UTC 2007-09-10 00:00:00 UTC Alison Barker Alison Barker [] Alison Barker [] [] [] [] HDRUK
  • Tools integration for Proteomics and Systems Biology

    1 November 2007

    Elixir node event
    Tools integration for Proteomics and Systems Biology https://tess.elixir-europe.org/events/tools-integration-for-proteomics-and-systems-biology 2007-11-01 09:00:00 UTC 2007-11-01 00:00:00 UTC Alison Barker Alison Barker [] Alison Barker [] [] [] [] HDRUK
  • Joint EBI-Wellcome Trust Proteomics workshop

    18 November 2007

    Elixir node event
    Joint EBI-Wellcome Trust Proteomics workshop https://tess.elixir-europe.org/events/joint-ebi-wellcome-trust-proteomics-workshop-b42d7793-7475-4f8e-9340-b695a6ab7e40 2007-11-18 09:00:00 UTC 2007-11-18 00:00:00 UTC Joint EBI-Wellcome Trust Proteomics workshop Joint EBI-Wellcome Trust Proteomics workshop [] [] [] [] [] HDRUK
  • The Bioinformatics Roadshow - Scottish Roadshow

    15 January 2008

    Elixir node event
    The Bioinformatics Roadshow - Scottish Roadshow https://tess.elixir-europe.org/events/the-bioinformatics-roadshow-scottish-roadshow-f2f34d67-ec4d-4f4a-8c87-37823d1291d2 2008-01-15 09:00:00 UTC 2008-01-15 00:00:00 UTC The Bioinformatics Roadshow - Scottish Roadshow The Bioinformatics Roadshow - Scottish Roadshow [] [] [] [] [] HDRUK
  • Transcriptomics

    28 January 2008

    Elixir node event
    Transcriptomics https://tess.elixir-europe.org/events/transcriptomics-5a2eabf5-97d8-4105-be7b-0b698ed04229 2008-01-28 09:00:00 UTC 2008-01-28 00:00:00 UTC Alison Barker Alison Barker [] Alison Barker [] [] [] [] HDRUK
  • Protein to Proteomes

    11 February 2008

    Elixir node event
    Protein to Proteomes https://tess.elixir-europe.org/events/protein-to-proteomes 2008-02-11 09:00:00 UTC 2008-02-11 00:00:00 UTC Alison Barker Alison Barker [] Alison Barker [] [] [] [] HDRUK
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