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4 events found

Keywords: nanosafety assessment 

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Content provider: NanoCommons 

  • 56th Eurotox Conference - Personalized nano-immunotoxicology for the workplace

    27 September 2021

    56th Eurotox Conference - Personalized nano-immunotoxicology for the workplace https://tess.elixir-europe.org/events/56th-eurotox-conference-personalized-nano-immunotoxicology-for-the-workplace In vitro immuno-nanotoxicological methods that take pre-existing conditions into account Abtract: In the workplace environment, where nanoparticles (NPs) may reach higher concentrations, the co-existence of allergens may result in new combinations of NPs with allergens. Normal as well as pre-disposed individuals, suffering from pre-existing allergic sensitization, may thus be affected by inhalation of aerosols carrying these new combinations having different immunological consequences. Recently, epithelial barrier integrity has been recognized to exert major impacts on the general health status of humans (epithelial barrier hypothesis, https://doi.org/10.1038/s41577-021-00538-7), responsible for increase in allergy, autoimmunity and other chronic conditions. Moreover, for therapeutic approaches allergens are conjugated with different types of particulate matter, which serve as adjuvants, to boost the immune reaction or, in the particular case of allergen-specific immunotherapy, to drive immunomodulation from a type 2 to a more tolerogenic response. Here, the variety of materials can range from classical alum-based to more sophisticated nanovaccine carriers. Decreasing the size-range into the nano-scale goes in line with specific surface-related effects, known as protein corona formation, having impact not just on the NP itself, but even more importantly on the bound allergen. We have recently established a suite of in vitro assays that elucidate effects at a structural and molecular level with a particular focus on responses specific for sensitized individuals, to sort out alterations in the allergic effector function. Data enrichment from in vitro experimentation may be accomplished by use of suitable in silico modeling tools. Therefore, protein corona prediction was tested and evaluated for its potential to complement the experimental workflow. Ultimately, combined in vitro and in silico data including comprehensive metadata was uploaded to the NanoCommons Knowledge Base to aid data FAIRness, i.e. Findability, Accessibility, Interoperability, and Reusability. In conclusion, such integrated workflows can help in early-stage decision-making processes in therapeutic development, and hence, promote safe-by design approaches in nanomedical innovation, as well as – in combination with in silico-based exposure-relevant dose-finding – serve for risk monitoring at specifically loaded areas, e.g., workplaces, taking into account pre-existing conditions such as allergic sensitization. Acknowledgments: This work was supported by the international PhD program “Immunity in Cancer and Allergy - ICA” of the Austrian Science Fund (FWF, grant no. W01213), the EU H2020 projects NanoRigo and NanoCommons (grant no.s 814530 and 731032, respectively), and the Allergy-Cancer-BioNano (ACBN) Research Center of the Paris Lodron University of Salzburg (PLUS). 2021-09-27 18:00:00 UTC 2021-09-27 20:00:00 UTC Martin Himly, PLUS, Chair of EU NanoSafety Cluster WG-A [] NanoCommonsNanoRigoAustrian Science Fund grant W01213 Life Science Researchers 300 meetings_and_conferences [] nanosafety assessmentdata FAIRnessadvanced models
  • Total NanoSafe Hybrid Conference - From Molecules to Public Health

    11 - 12 November 2021

    Braga, Portugal

    Total NanoSafe Hybrid Conference - From Molecules to Public Health https://tess.elixir-europe.org/events/total-nanosafe-hybrid-conference-from-molecules-to-public-health Total NanoSafe Hybrid Conference – From Molecules to Public Health, Nov 11 & 12, 2021 at the International Nanotechnology Laboratories in Braga, Portugal. The ‘Total-Nanosafe’ Hybrid Conference is bringing experts in different fields related to the use of nanomaterials, nanotechnology and how these are related to different aspects of safety, regarding health and environment. Submit Your Abstract: The deadline for submitting your abstract to the event TOTAL - NANOSAFE: From Molecules to Public Health is approaching! You have until October 26th to send it to us and take an active part in this International Conference. Show us your work in nanomaterials, nanotechnology and how these are related to different aspects of safety, regarding health and the environment, specifically in these topics: - Nanomaterials Toxicity - Cells and Organs on Chip - Cheminformatics and in Silico Tools - Epigenetics List of speakers: Day One (November 11th) Keynote talk: Flemming Cassee Session 1: Toxicological assessment of Nanomaterials - Martin Himly - Peter Hoet - Hanna Karlsson - Vania Vilas-Boas Break Keynote talk: Peter Loskill Session 2: Complex cell culture and organ-on-chip - Arno Gutleb - Nina Hobi or Janick Stucki - Lorena Dieguez - Liliana Teixeira - Ana Ribeiro Day Two (November 12th) Keynote Speaker: Jose Luís Medina Franco Session 3: Cheminformatics and in silico tools - Andrey Toropov - Timothy E H Allen - Eli Fernández de Gortari Break Session 4: From molecules to public health - Begoña Espiña - Basak Engin - Manosij Ghosh - Pauliina Damdimopoulou - Tim Nawrot - Nivedita Chatterjee 2021-11-11 09:00:00 UTC 2021-11-12 17:00:00 UTC International Nanotechnology Laboratories - INL, Braga, Portugal International Nanotechnology Laboratories - INL Braga Portugal INL NanoCommons Life Science Researchers 300 meetings_and_conferences [] nanosafety assessmentdata FAIRnessadvanced cellular modelsin silico predictionprotein corona formationadverse outcome pathwaymolecular initiating events
  • The NanoCommons Knowledge Base: how to find all data for one nanomaterial across multiple data sources

    2 December 2021

    The NanoCommons Knowledge Base: how to find all data for one nanomaterial across multiple data sources https://tess.elixir-europe.org/events/the-nanocommons-knowledge-base-how-to-find-all-data-for-one-nanomaterial-across-multiple-data-sources On Thursday 2nd December 2021, the NanoCommon team, in a joint initiative with the EU NanoSafety Cluster, will offer an online workshop/hackathon on their Knowledge Base (NC KB), termed “The NanoCommons Knowledge Base: how to find all data for one nanomaterial across multiple data sources”. Data retrievals & uploads will be showcased using the features of the NC KB (https://ssl.biomax.de/nanocommons/cgi/login_bioxm_portal.cgi) interlinking the results from several large projects’ real data sets and corresponding metadata sufficing the need for data FAIRness (Findability, Accessibility, Interoperability, Reusability) and its diverse functionalities will be presented in an interactive manner, thus, be tested for fitness-for-purpose by the attendees’ demands. Attendees will be able to get hands-on experience during this 2 h workshop/hackathon. Expectation: Willing to learn new things and active participation in the interactive webinar. The webinar will take place on Thursday December 2nd from 15:00 till 17:00 h CET. Feel free to join and please do not forget to register here: https://ukri.zoom.us/meeting/register/tJYtf-upqDMvGdRpjZos9mtYH0ZVG-1Ui7hq After registering, you will receive a confirmation email containing information about joining the workshop. Please, be aware that some personal information may be collected for statistical purposes, however, in a blinded and anonymous way. The workshop will be partially recorded for educational purposes. You will find updates with more information about NanoCommons and training materials here. Feel free to redistribute this information within your projects and networks. We are happy to have as many participants as possible and to help the community with the FAIRification of their data by offering insight into fully exploring and linking available data resources in a more straightforward way. The NanoCommons team will be happy to answer your questions and to guide you in your requests! 2021-12-02 15:00:00 UTC 2021-12-02 17:00:00 UTC Martin Himly, PLUS, Chair of EU NanoSafety Cluster WG-A BiomaxPLUSUKCEHBNNUoB7p9 NanoCommonsNanoSolveIT mixed audience workshops_and_courses [] data FAIRnessmetadata completenessnanosafety assessmentnanotoxicologyOntologies
  • Electronic Lab Notebooks - Demo of NanoCommons-powered Features

    13 January 2022

    Electronic Lab Notebooks - Demo of NanoCommons-powered Features https://tess.elixir-europe.org/events/electronic-lab-notebooks-demo-of-nanocommons-powered-features On Thursday, January 13th 2022, the NanoCommons team, in a joint initiative with the NanoSafety Cluster, is offering an interactive online workshop on implementing Electronic Laboratory Notebooks (ELNs) for nanosafety assessment. Under the subtitle “Electronic Lab Notebooks - Demo of NanoCommons-powered Features”, you will learn how to establish a experimental workflows using electronic lab notebooks (ELNs). This starts with an introduction to the NanoCommons-powered features on how to manage, modify, create, and import protocols for assays. Tasks can be defined and assigned to different users and/or groups. Finally, data (incl. all relevant metadata) can be exported resulting in reports that facilitate data FAIRness. Technology advancement, the emergence of nanoinformatics and FAIR data principles implementation have increased the need for high-quality datasets. To achieve this, the data produced through academia, industry and regulatory bodies needs to be properly curated, to contain sufficient metadata and to be semantically annotated. In this way, data can be accessible and readable from both humans and machines, making it possible to be queried and mined using appropriate systems. One of the main objectives of NanoCommons is to promote the FAIR data principles, cross-project collaboration and data interoperability. This will make it possible to offer the nanosafety community high quality data that can be combined to produce big datasets and be used in novel modelling, machine learning, deep learning and AI techniques. We aim to achieve this by implementing data management processes covering the entire data lifecycle, and by moving the data curation process to the data generators, in line with the concept of Data Shepherding. Capturing the data and metadata as they are produced will save substantial time and resources, while resulting in higher quality datasets. ELNs can be implemented, through cloud services or locally, into everyday experimental practice streamlining and simplifying experimental and computational workflows, practices and data capturing. Target audience: Bench and computational scientists looking into automated ways to capture and retrieve data and making them available to the community. Expectation: Willing to learn new things and active participation in the interactive training session. The hackathon will take place on Thursday, January 13th from 15:00 till 17:00 h CET. Feel free to join and please do not forget to register here asap so we can tailor the workshop for your needs. Please, be aware that some personal information may be collected for statistical purposes, however, in a blinded and anonymous way. The workshop will be partially recorded for educational purposes. You will find updates with more information about NanoCommons and training materials here. Feel free to redistribute this information within your projects and networks. We are happy to have as many participants as possible and to help the community with the FAIRification of their data by using ELNs allowing nanosafety data annotation in a more straightforward way. The NanoCommons team will be happy to answer your questions and to guide you in your requests! 2022-01-13 15:00:00 UTC 2022-01-13 17:00:00 UTC Martin Himly, PLUS, Chair of EU NanoSafety Cluster WG-A University of Brimingham NanoCommons mixed audience 50 workshops_and_courses [] data FAIRnessmetadata completenesslife sciencesnanosafety assessment

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