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  • FEBS 2018 Advanced Course

    23 - 25 May 2018

    Bologna, Italy

    FEBS 2018 Advanced Course **Application deadline: _15 April 2018_** **Deadline dor applying to FEBS Youth Travel Funds (YTF): _28 February 2018_** The workshop intends to present the state-of-fhe-art of the computational tools for interpreting at the molecular level the effects that genome variations induce in the cell system, contributing to fill the knowledge gap between genotype and phenotype. NGS techniques allow detection of the differences in genetic sequences and in gene expression that can be associated to different phenotypes, and statistical methods can estimate a significance level for each association. However, the exploitation of genetic association data requires elucidation of how variations affect the structure of macromolecules and their interaction patterns and how biological processes and pathways are hampered. Proteins, their stability and their relationships in interactomes will be the central topic. Furthermore, a particular regard will be given to the regulation at the transcriptional and translational levels, as derived from epigenomic and ribosome profiling data. Computational tools are absolutely necessary to perform the analysis of massive amounts of biomedical data and modern techniques for database integration, non parametric statistics, machine-learning and in particular deep-learning approaches, can have a huge impact in the field. The exploitation of data in the applicative domains, and in particular in translational and stratified medicine, strongly rely on the availability of computational methods able to extract, elaborate and generalise biologically relevant information The workshop aims at presenting the state-of-the-art of computational methods for genome interpretation and collects expert scientists from both experimental biomedicine and computational biology. The mixing of competences is fundamental for generating significant advancements, and the proposed workshop . The format of the workshop allows extensive interaction among students and lecturers, and offers to young researchers the possibility of presenting their work at poster sessions and with short selected talks. 2018-05-23 09:00:00 UTC 2018-05-25 18:00:00 UTC Pier Luigi Martelli (University of Bologna), Mauno Vihinen (Lund University) Dipartimento di Storia Culture Civiltà - Università di Bologna, 2, Piazza San Giovanni in Monte, Bologna, Italy Dipartimento di Storia Culture Civiltà - Università di Bologna, 2, Piazza San Giovanni in Monte Bologna Città Metropolitana di Bologna Italy 40124 University of Bologna, Italy Federation of European Societies of Biochemistry (FEBS) postdoctoral researchersPhD Students 80 workshops_and_courses first_come_first_served Computational BiologyGenotype-Phenotype relationshipHuman genetic variationProtein stabilityProtein functionNGS data analysis

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