Start: Saturday, 15 June 2019 @ 09:00

End: Saturday, 15 June 2019 @ 00:00

Venue: Gothenburg

Country: Sweden

Description:

In this workshop, we will introduce Open Targets Genetics Portal as part of the Open Targets ecosystem, highlighting variant-centric statistical evidence for prioritizing candidate causal variants at trait-associated loci, and identifying potential drug targets. We will present POSTGAP, a pipeline which merges genetic associations curated from literature with functional genomics, epigenetic and expression data (e.g., eQTL, promoter capture Hi-C, DNase hypersensitivity sites, regulatory elements) to resolve association signals at a locus and link each variant to its target gene(s) using a single evidence score. The portal also incorporates pre-computed fine-mapping at trait-associated loci across hundreds of UK Biobank phenotypes as well as cross-trait colocalization, furthering drug repurposing opportunities. This workshop will enable you to effectively use Open Targets Genetics to gain biological insight, prioritize genes, and inform target decision-making. Intended Audience: Attendees interested in the translational application of genetics and genomics with an emphasis on the identification of target genes of trait-associated loci, drug target identification, prioritisation and repurposing. Participants should bring their laptops for exploration of the Open Targets Genetics Portal in situ.

Event type:
  • Workshops and courses

Keywords: Open Targets

Open Targets Genetics at ESHG https://tess.elixir-europe.org/events/open-targets-genetics-at-eshg In this workshop, we will introduce Open Targets Genetics Portal as part of the Open Targets ecosystem, highlighting variant-centric statistical evidence for prioritizing candidate causal variants at trait-associated loci, and identifying potential drug targets. We will present POSTGAP, a pipeline which merges genetic associations curated from literature with functional genomics, epigenetic and expression data (e.g., eQTL, promoter capture Hi-C, DNase hypersensitivity sites, regulatory elements) to resolve association signals at a locus and link each variant to its target gene(s) using a single evidence score. The portal also incorporates pre-computed fine-mapping at trait-associated loci across hundreds of UK Biobank phenotypes as well as cross-trait colocalization, furthering drug repurposing opportunities. This workshop will enable you to effectively use Open Targets Genetics to gain biological insight, prioritize genes, and inform target decision-making. Intended Audience: Attendees interested in the translational application of genetics and genomics with an emphasis on the identification of target genes of trait-associated loci, drug target identification, prioritisation and repurposing. Participants should bring their laptops for exploration of the Open Targets Genetics Portal in situ. 2019-06-15 09:00:00 UTC 2019-06-15 00:00:00 UTC Gothenburg, Sweden Gothenburg Sweden [] [] [] workshops_and_courses [] Open Targets