Application deadline: 15 April 2018

Deadline dor applying to FEBS Youth Travel Funds (YTF): 28 February 2018

The workshop intends to present the state-of-fhe-art of the computational
tools for interpreting at the molecular level the effects that genome
variations induce in the cell system, contributing to fill the knowledge
gap between genotype and phenotype.

NGS techniques allow detection of the differences in genetic sequences and
in gene expression that can be associated to different phenotypes, and
statistical methods can estimate a significance level for each
association. However, the exploitation of genetic association data
requires elucidation of how variations affect the structure of
macromolecules and their interaction patterns and how biological processes
and pathways are hampered. Proteins, their stability and their
relationships in interactomes will be the central topic. Furthermore, a
particular regard will be given to the regulation at the transcriptional
and translational levels, as derived from epigenomic and ribosome
profiling data.

Computational tools are absolutely necessary to perform the analysis of
massive amounts of biomedical data and modern techniques for database
integration, non parametric statistics, machine-learning and in particular
deep-learning approaches, can have a huge impact in the field. The
exploitation of data in the applicative domains, and in particular in
translational and stratified medicine, strongly rely on the availability
of computational methods able to extract, elaborate and generalise
biologically relevant information

The workshop aims at presenting the state-of-the-art of computational
methods for genome interpretation and collects expert scientists from both
experimental biomedicine and computational biology. The mixing of
competences is fundamental for generating significant advancements, and
the proposed workshop .

The format of the workshop allows extensive interaction among students and
lecturers, and offers to young researchers the possibility of presenting
their work at poster sessions and with short selected talks.