Open Targets is an innovative, large-scale, multi-year, public-private partnership that uses human genetics and genomics data for systematic drug target identification and prioritisation.
Bioinformatics for Discovery
18 October 2018
United KingdomBioinformatics for Discovery https://www.ebi.ac.uk/training/events/2019/bioinformatics-discovery-2 https://tess.elixir-europe.org/events/bioinformatics-for-discovery-f51fe25c-6f52-4589-b79c-5f829803f89a In this workshop, we will introduce the Open Targets Platforms and some standalone tools to aid drug target identification and prioritisation. This workshop is part of the the Bioinformatics for Discovery course and is is aimed at bench biologists working in the area of discovery science who want to learn more about bioinformatics tools and resources. No prior knowledge of bioinformatics is required and no experience of programming or the use of Unix / Linux is necessary. . 2018-10-18 09:00:00 UTC 2018-10-18 00:00:00 UTC Hinxton, United Kingdom Hinxton United Kingdom    workshops_and_courses  Open Targets
Workshop at ASHG
18 October 2018
United States of AmericaWorkshop at ASHG http://www.ashg.org/2018meeting/asp/soe/webroot/soe.shtml#?search=Open%20Targets https://tess.elixir-europe.org/events/workshop-at-ashg In this workshop, we will introduce Open Targets Genetics Portal as part of the Open Targets ecosystem, highlighting variant-centric statistical evidence for prioritizing candidate causal variants at trait-associated loci, and identifying potential drug targets. We will present POSTGAP, a pipeline which merges genetic associations curated from literature with functional genomics, epigenetic and expression data (e.g., eQTL, promoter capture Hi-C, DNase hypersensitivity sites, regulatory elements) to resolve association signals at a locus and link each variant to its target gene(s) using a single evidence score. The portal also incorporates pre-computed fine-mapping at trait-associated loci across hundreds of UK Biobank phenotypes as well as cross-trait colocalization, furthering drug repurposing opportunities. This workshop will enable you to effectively use Open Targets Genetics to gain biological insight, prioritize genes, and inform target decision-making. Intended Audience: Attendees interested in the translational application of genetics and genomics with an emphasis on the identification of target genes of trait-associated loci, drug target identification, prioritisation and repurposing. Participants should bring their laptops for exploration of the Open Targets Genetics Portal in situ. 2018-10-18 09:00:00 UTC 2018-10-18 00:00:00 UTC San Diego, United States of America San Diego United States of America    workshops_and_courses  Open Targets